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2008•The Journal of Clinical AnesthesiologyRequires access

Therapeutic effect of penehyclidine on oleic acid-induced acute lung injury in rats

Mengying Li

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Abstract

Objective To investigate the therapeutic effect of penehyclidine in rats with oleic acid-induced acute lung injury(ALI).Methods Forty male SD rats were randomized equally into four groups of normal control (group Ⅰ),ALI (group Ⅱ),penehyclidine inhalation (group Ⅲ),and intravenous penehyclidine (group Ⅳ). Blood pressure(BP),pulmonary artery pressure(PAP),arterial and mixed venous blood gas analysis were performed every 60minutes during the experiment. The neutrophils and total protein(TP)content in bronchoalveolar lavage fluid (BALF),lung myeloperoxidase(MPO) activity were determined after the experiments. Results PAP and PaO2/FiO2 were improved in group Ⅲ and Ⅳ compared with those in group Ⅰ and Ⅱ.TP,neutrophil accout and differentiation in BALF and lung MPO were lower in group Ⅲ and Ⅳ than those in group Ⅱ. Conclusion Penehyclidine inhalation is better than intravenous penehyclidine in attenuating ALI induced by oleic acid in rats.

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Objective To investigate the therapeutic effect of penehyclidine in rats with oleic acid-induced acute lung injury(ALI).Methods Forty male SD rats were randomized equally into four groups of normal control (group Ⅰ),ALI (group Ⅱ),penehyclidine inhalation (group Ⅲ),and intravenous penehyclidine (group Ⅳ). Blood pressure(BP),pulmonary artery pressure(PAP),arterial and mixed venous blood gas analysis were performed every 60minutes during the experiment. The neutrophils and total protein(TP)content in bronchoalveolar lavage fluid (BALF),lung myeloperoxidase(MPO) activity were determined after the experiments. Results PAP and PaO2/FiO2 were improved in group Ⅲ and Ⅳ compared with those in group Ⅰ and Ⅱ.TP,neutrophil accout and differentiation in BALF and lung MPO were lower in group Ⅲ and Ⅳ than those in group Ⅱ. Conclusion Penehyclidine inhalation is better than intravenous penehyclidine in attenuating ALI induced by oleic acid in rats.

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Available abstract

Objective To investigate the therapeutic effect of penehyclidine in rats with oleic acid-induced acute lung injury(ALI).Methods Forty male SD rats were randomized equally into four groups of normal control (group Ⅰ),ALI (group Ⅱ),penehyclidine inhalation (group Ⅲ),and intravenous penehyclidine (group Ⅳ). Blood pressure(BP),pulmonary artery pressure(PAP),arterial and mixed venous blood gas analysis were performed every 60minutes during the experiment. The neutrophils and total protein(TP)content in bronchoalveolar lavage fluid (BALF),lung myeloperoxidase(MPO) activity were determined after the experiments. Results PAP and PaO2/FiO2 were improved in group Ⅲ and Ⅳ compared with those in group Ⅰ and Ⅱ.TP,neutrophil accout and differentiation in BALF and lung MPO were lower in group Ⅲ and Ⅳ than those in group Ⅱ. Conclusion Penehyclidine inhalation is better than intravenous penehyclidine in attenuating ALI induced by oleic acid in rats.

Key concepts: Medicine, Myeloperoxidase, Bronchoalveolar lavage, Anesthesia, Inhalation, Lung, Oleic acid, Venous blood

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