Antimicrobial resistance of Klebsiella pneumoniae and the nosocomial infection of ESBLs-producing strains

Objective To survey the drug-resistance of Klebsiella pneumoniae to 17 kinds of antibiotics and the nosocomial infection of ESBLs-producing strains. Methods After Klebsiella pneumoniae was collected, isolated and identified, drug-resistance experiment was measured with K-B method and ESBLs-producing strains detected according to NCCLS recommended method. Results Unrepeatable 128 strains of Klebsiella pneumoniae were obtained from ShiYan city, 60 of which were ESBLs-producing(46.88%), its drug-resistance rate of Klebsiella pneumoniae to Ampicillin, Pipercillin, Amoxicillin-clavuanic acid, Sulbactam-cefoperazona, Cefazolin, Cefuroxime sodium, Ceftazidime, Cefotaxime, Aztreonam, Imipenem, Ciprofloxacin, Gentamicin, Amikacin, Nalidixicacid, Chloramphenicol, Tetracycline, Cefepime were 100%, 96.7%, 42.6%, 47.2%, 96.7%, 96.7%, 18.3%, 71.7%, 43.3%, 0%, 31.7%, 86.7%, 66.7%, 66.7%, 61.5%, 64.9%, 36.1%, respectively. The drug-resistance rates of ESBLs-producing strains were significantly different from the EBSLs-nonproducing strains ( P 0.01) with the exception of Imipenem and Ampicillin. Conclusion Imipenem may be the first choice to treat the infection of EBSLs-producing strain of Klebsiella pneumoniae . Measures should be taken to prevent the nosocomial infection of Klebsiella pneumoniae.