The correlation and clinical pathological significance of the expression of HIF-Iα and VEGF protein in esophageal squamous cell carcinoma

Objective To explore the relationship of the expression of HIF-Ⅰα,VEGF protein and the occurrence,invasion and metastasis in esophageal squamous cell carcinoma.Methods SP immunohistochemical method was used to detect the expression of HIF-Ⅰα,VEGF protein in 49 cases of esophageal squamous cell carcinoma specimens and 32 cases of normal esophageal epithelium.Results The expression of HIF-Ⅰα protein was closely correlated with the infiltration and lymphatic metastasis in esophageal squamous cell carcinoma(P0.05),not correlated with the tumor grade(P0.05);VEGF protein had no correlation with the tumor grade and infiltration but was correlated with lymphatic metastasis in esophageal squamous cell carcinoma(P0.05).The expression rates of HIF-Ⅰα and VEGF protein were 51.0% and 67.3% in carcinoma,obviously higher than that in normal esophageal epithelium specimens 0.0% and 0.0%(P0.05).And there was positive correlation between the expression of HIF-Ⅰα and VEGF protein(P0.05).Conclusion HIF-Ⅰα and VEGF play important roles in the metastasis and carcinomatous change of the mucosa epithelium in esophageal carcinoma.United examining HIF-Ⅰαand VEGF can become an objective target to evaluate potential power of invasion and lymph node metastasis of esophageal squamous cell carcinoma,it had a great significance to the judgement of prognosis in esophageal squamous cell carcinoma.