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Expression of Caspase-3 in the hippocampus of pentylenetetrazole-kindled rats

Yinhua Wang

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Abstract

Objective To investigate the expression of Caspase 3 in the hippocampus of acutely pentylenetetrazole-kindled rats. Methods Acutly kindled rat model was made by intraperitoneal injection of pentylenetetrazole. The hippocampal expression of Caspase 3 mRNA was showed through reverse transcription polymerase chain reaction (RT PCR) method. Results Caspase 3 mRNA was significantly up regulated in hippocampal neurons following PTZ induced epilepsy and existed for several days(at least from 8h to 5d after epilepsy). Conclusion The result indicates that Caspase 3 may be activated at transcriptional level during neuronal apoptosis after epilepsy.

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What this paper is about

Objective To investigate the expression of Caspase 3 in the hippocampus of acutely pentylenetetrazole-kindled rats. Methods Acutly kindled rat model was made by intraperitoneal injection of pentylenetetrazole. The hippocampal expression of Caspase 3 mRNA was showed through reverse transcription polymerase chain reaction (RT PCR) method. Results Caspase 3 mRNA was significantly up regulated in hippocampal neurons following PTZ induced epilepsy and existed for several days(at least from 8h to 5d after epilepsy). Conclusion The result indicates that Caspase 3 may be activated at transcriptional level during neuronal apoptosis after epilepsy.

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Available abstract

Objective To investigate the expression of Caspase 3 in the hippocampus of acutely pentylenetetrazole-kindled rats. Methods Acutly kindled rat model was made by intraperitoneal injection of pentylenetetrazole. The hippocampal expression of Caspase 3 mRNA was showed through reverse transcription polymerase chain reaction (RT PCR) method. Results Caspase 3 mRNA was significantly up regulated in hippocampal neurons following PTZ induced epilepsy and existed for several days(at least from 8h to 5d after epilepsy). Conclusion The result indicates that Caspase 3 may be activated at transcriptional level during neuronal apoptosis after epilepsy.

Key concepts: Hippocampal formation, Hippocampus, Epilepsy, Apoptosis, Intraperitoneal injection, Caspase 3, Messenger RNA, Reverse transcription polymerase chain reaction

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