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2009•Journal of Brain and Nervous DiseasesRequires access

Expression of AIF in the hippocampus of pentylenetetrazole-kindled rats

Zhiqi Shi

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Abstract

Objective To investigate the expression of AIF mRNA in the hippocampus of status epilepticus rats,which kindled by pentylenetetrazol.Methods SE rat model was made by intraperitoneal injection of pentylenetetrazole.The hippocampal expression of AIF mRNA was showed through reverse transcription polymerase chain reaction (RT-PCR) method.Results AIF mRNA was significantly up-regulated in hippocampal neurons following PTZ-induced epilepsy and existed for several days (at least from 6h to 2d after epilepsy ).Conclusion The result indicates that AIF may be activated at transcriptional level during neuronal apoptosis after epilepsy.

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What this paper is about

Objective To investigate the expression of AIF mRNA in the hippocampus of status epilepticus rats,which kindled by pentylenetetrazol.Methods SE rat model was made by intraperitoneal injection of pentylenetetrazole.The hippocampal expression of AIF mRNA was showed through reverse transcription polymerase chain reaction (RT-PCR) method.Results AIF mRNA was significantly up-regulated in hippocampal neurons following PTZ-induced epilepsy and existed for several days (at least from 6h to 2d after epilepsy ).Conclusion The result indicates that AIF may be activated at transcriptional level during neuronal apoptosis after epilepsy.

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Available abstract

Objective To investigate the expression of AIF mRNA in the hippocampus of status epilepticus rats,which kindled by pentylenetetrazol.Methods SE rat model was made by intraperitoneal injection of pentylenetetrazole.The hippocampal expression of AIF mRNA was showed through reverse transcription polymerase chain reaction (RT-PCR) method.Results AIF mRNA was significantly up-regulated in hippocampal neurons following PTZ-induced epilepsy and existed for several days (at least from 6h to 2d after epilepsy ).Conclusion The result indicates that AIF may be activated at transcriptional level during neuronal apoptosis after epilepsy.

Key concepts: Pentylenetetrazol, Status epilepticus, Hippocampal formation, Epilepsy, Hippocampus, Messenger RNA, Kindling, Apoptosis

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