A study on the relationship of hyperuricemia with diabetic hypertention and diebetic nephropathy

Objective To discuss the relationship among hyperuricemia, diabetes-combined high blood pressure and nephropathy,by detecting the level of the blood uric acid(UA)in the patients with type 2 diabetes(T2DM). Methods Ninety-eight cases of T2DM were collected, and were divided into 3 groups: the one with non-combined-disease(only with diabetic syndrome), the one with combined high blood pressure(DMEH), the one with combined nephropathy(DN), the level of blood uric acid (UA),creatinin(Cr), blood urea nitrogen (BUN), free blood sugar(FBG), saccharified hemoglobin (HbAlc), free insulin (FINS) and blood fat was measured respectively. Results The level of UA in all experimental groups was significantly higher than that in contrast one, P values were respectively:P0.05,P 0.01,P0.05; the level of Cr in DN group was significantly higher than that in contrast one and T2DM one, P values were respectively: P 0.001 and P 0.01; multiple regression analysis showed that UA in the T2DM patients was positively correlated with DBP, TG and Cr significantly, while it was negatively correlated with HDL-C; UA was positively correlated with FINS. Conclusion Diabetic high blood uric acid disease might affect the process of occurrence and development of high blood pressure and nephropathy. The detection of them could be a premonitory of T2DM-combined disease.