EXPRESSION AND SIGNIFICANCE OF EGFR AND C-ERBB-2 IN COLORECTAL CARCINOMA

Objective:To study the expression of EGFR and C-erbB-2 protein in human colorectal carcinoma and their relationships with clinical features of colorectal carcinoma.Methods:SP immunohistochemical stain was used to detect the expression of EGFR and C-erbB-2 protein in 15 cases normal colon mucosa and 50 cases colorectal carcinoma.Results:The EGFR and C-erbB-2 protein expression in colorectal carcinoma were obviously higher than normal colon mucosa(P0.01).In colorectal carcinoma,the EGFR and C-erbB-2 protein expression all had relations with differentiation,lymph node metastasis,infiltration depth and Duke's stage(P0.01,P0.05).In colorectal carcinoma,the expression of EGFR had obvious positive correlation with C-erbB-2 expression(P0.01).Conclusions: EGFR and C-erbB-2 protein can be acted as index to judge malignant degree and prognosis assessment of colorectal carcinoma,and has certain significance for guiding postoperative chemotherapy or targeted therapy.