Relationship between Expression of EGFR,c-erbB-2 and VEGF with Clinicopathological Characteristics in Human Colorectal Carcinoma

Objective To study the correlation of EGFR、c-erbB-2 and VEGF expression in colorectal carcinoma and their significances to clinicopathological character.Methods We studied the expression level of EGFR、c-erbB-2 and VEGF in 61 cases of colorectal carcinoma by Envision method and analysed the correlation of the expression level and colorectal carcinoma clinicopathological character by Multiple linear regression.Results The respectively high expression rate of EGFR、c-erbB-2 and VEGF was 49.2%,73.8% and 70.5%.Multiple linear regression shows that the high expression of EGFR、c-erbB-2 and VEGF were related with the tumor size、lymph nodes metastasis、liver metastasis and Dukes' stages,but not correlated with gender and age.Conclusion The results suggest that the high expression of EGFR、c-erbB-2 and VEGF is an useful tool for providing information about the malignant degree,prognosis,and may be as a gaiding in postoperative chemotherapy selection for patients with colorectal carcinoma.