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Relationship between the VEGF and pathological factor as well as prognostic significance in breast cancer

Zhongli Zhan

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Abstract

Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in breast cancer and to evaluate the prognostic significance of VEGF.Methods: A total of 109 patients were selected to this study from the years l985 to l986. VEGF and microvessel density(MVD) were analyzed by immunohistochemistry in primary lesions in these patients. Resu1ts: High expression group of VEGF and low expression group of VEGF had significant difference in lymph node involvement(52.2% and 23.5%, P0.05) and histologic grade. There was a trend of increase of expression level of VEGF compared with decrease of 5-years 10-years 15-years survival but which hadn't significant difference.VEGF expression is not connected with tumor size,menopause and estrogen receptor. Conclusion: VEGF expression is significantly related to the lymph node involvement and histologic grade and may be used as one of the prognostic indicators in breast cancer.

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Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in breast cancer and to evaluate the prognostic significance of VEGF.Methods: A total of 109 patients were selected to this study from the years l985 to l986. VEGF and microvessel density(MVD) were analyzed by immunohistochemistry in primary lesions in these patients. Resu1ts: High expression group of VEGF and low expression group of VEGF had significant difference in lymph node involvement(52.2% and 23.5%, P0.05) and histologic grade. There was a trend of increase of expression level of VEGF compared with decrease of 5-years 10-years 15-years survival but which hadn't significant difference.VEGF expression is not connected with tumor size,menopause and estrogen receptor. Conclusion: VEGF expression is significantly related to the lymph node involvement and histologic grade and may be used as one of the prognostic indicators in breast cancer.

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Available abstract

Objective: To investigate the expression of vascular endothelial growth factor (VEGF) in breast cancer and to evaluate the prognostic significance of VEGF.Methods: A total of 109 patients were selected to this study from the years l985 to l986. VEGF and microvessel density(MVD) were analyzed by immunohistochemistry in primary lesions in these patients. Resu1ts: High expression group of VEGF and low expression group of VEGF had significant difference in lymph node involvement(52.2% and 23.5%, P0.05) and histologic grade. There was a trend of increase of expression level of VEGF compared with decrease of 5-years 10-years 15-years survival but which hadn't significant difference.VEGF expression is not connected with tumor size,menopause and estrogen receptor. Conclusion: VEGF expression is significantly related to the lymph node involvement and histologic grade and may be used as one of the prognostic indicators in breast cancer.

Key concepts: Medicine, Pathological, Immunohistochemistry, Breast cancer, Vascular endothelial growth factor, VEGF receptors, Lymph node, Internal medicine

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