2006•The Chinese Journal of Modern Applied PharmacyRequires access
Effect of Mongolia drug TGLG-1 on Super Oxidation of the Lipide in Hyperlipidemic Rats
Guilian Zhang, Wu Gang, Pang Dong-wei, Wang Deng-kui, Zhao Shuzhong, Cheng Xiang-hui, Xiuying Yan
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Abstract
OBJECTIVE To study the effect of TGLG-1 on super oxidation of the lipide of hyperlipidemic rats.METHODS To establish the model of hyperlipidemic rats.The experimental hyperlipidemic rats were!divided into four groups.Among them,one group was received physiological saline by ig administration as hyperlipidemic control.Three groups were respectively treated with TGLG-1 1g/mL,2g/mL,3g/mL by ig administration.The treatment were carried out 21 days,then the serum lipids of each group were determined.RESULTS Compared with the hyperlipidemic control group,it is found that TGLG-1 could significantly increase the content of NO in the serum of experimental groups(P0.05,P0.01) in medium dose group and high dose group,and the content of MDA in the liver significantly increase in the high group compared with the hyperlipidemic rats.CONCLUSION TGLG-1 has the effect to the content of NO in the serum and MDA in the liver of rats.