2006•The Chinese Journal of Modern Applied PharmacyRequires access

Effect of Mongolia drug TGLG-1 on serum lipids in hyperlipidemic rats

Gang Wu

Abstract

OBJECTIVE To study the adjustive effect of TGLG-1 on the level of serum lipids in hyperlipidemic rats.METHODS The model of hyperlipidemic rats were established.The experimental hyperlipidemic rats were divided into four groups.Among them,one group was received physiological saline by ig administration as hyperlipidemic control.The other three groups were respectively treated with TGLG-1(4g/kg,8g/kg,16g/kg) by ig administration.After 21 days treatment,the serum lipids of each group were determined. RESULTS Compared with the hyperlipidemic control group,it is found that TGLG-1 could significantly decrease the level of cholesterol(TC),triglyceride(TG) and low density lipoprotein.cholesterol in the serum of experimental groups,as well as remarkably increase the level of high density lipoprotein.cholesterol and the value of(HLD-C)/TC in the serum of the hyperlipidemic rats.CONCLUSION TGLG-1 has the effect to decrease the content of the serum lipids and prevent hyperlipidemia disease.

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Key concepts: Hyperlipidemia, Triglyceride, Blood lipids, Saline, Internal medicine, High-density lipoprotein, Cholesterol, Chemistry