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2009•Chinese Journal of Laboratory DiagnosisRequires access

Expression and clinical significance of Ki-67 in ovarian cancer

Xiao­hong Zhang

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Abstract

Objective To study the Expression and clinical significance of Ki-67 in ovarian cancer.Methods Immunohistochemistrical SP method was used to detect the expression of Ki-67 in 15 cases of normal ovarian tissue and 15 cases of benign ovarian tumor and 60 cases ovarian cancer.Results Ki-67 was negatively expressed in normal ovarian tissues;The positive rate of Ki-67 was 33.3% in ovarian benign tumor,and was 75.0% in ovarian cancer.The more latter in clinical stage was and the more poorer in cell differentiation was,the more higher positive rate of Ki-67 was.The positive rate of Ki-67 was correlated with histodifferemtiation and clinical stages of ovarian cancer,but was uncorrelated with the pathological type.Conclusion Ki-67 played an important role in the development of ovarian cancer.

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What this paper is about

Objective To study the Expression and clinical significance of Ki-67 in ovarian cancer.Methods Immunohistochemistrical SP method was used to detect the expression of Ki-67 in 15 cases of normal ovarian tissue and 15 cases of benign ovarian tumor and 60 cases ovarian cancer.Results Ki-67 was negatively expressed in normal ovarian tissues;The positive rate of Ki-67 was 33.3% in ovarian benign tumor,and was 75.0% in ovarian cancer.The more latter in clinical stage was and the more poorer in cell differentiation was,the more higher positive rate of Ki-67 was.The positive rate of Ki-67 was correlated with histodifferemtiation and clinical stages of ovarian cancer,but was uncorrelated with the pathological type.Conclusion Ki-67 played an important role in the development of ovarian cancer.

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Available abstract

Objective To study the Expression and clinical significance of Ki-67 in ovarian cancer.Methods Immunohistochemistrical SP method was used to detect the expression of Ki-67 in 15 cases of normal ovarian tissue and 15 cases of benign ovarian tumor and 60 cases ovarian cancer.Results Ki-67 was negatively expressed in normal ovarian tissues;The positive rate of Ki-67 was 33.3% in ovarian benign tumor,and was 75.0% in ovarian cancer.The more latter in clinical stage was and the more poorer in cell differentiation was,the more higher positive rate of Ki-67 was.The positive rate of Ki-67 was correlated with histodifferemtiation and clinical stages of ovarian cancer,but was uncorrelated with the pathological type.Conclusion Ki-67 played an important role in the development of ovarian cancer.

Key concepts: Ovarian cancer, Ki-67, Pathological, Clinical significance, Medicine, Ovarian tumor, Cancer, Stage (stratigraphy)

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