Expression of ki-67 in breast cancer and its clinical siganificance

Objective To investigate the expressing of Ki-67 in breast cancer tissues and explore the relationship between it and the clinic pathology characteristics.Methods Immunohistochemical SP was used to investigate Ki-67,ER,PR,C-erbB-2 expression in 120 cases of female breast cancer.Analysis the relatiouship between Ki67 and ER,PR,C-erbB-2,tunor size,lymph node metastasis,patients age,menstruation state and clinic pathology characteristics.Results Six cases' Ki-67 expression in 120 eases of female patients with breast cancer tissue were (-) (5％),36 cases' ki-67 expression were (+) (30％),31 cases Ki-67 Expression were (+ +)(25.83％),37 cases' Ki-67 expression were (+ + +) 39.17％.The expression of ki-67 did not correlate with the expression of C-crbB-2,tumor size,lymph node metastasis,patients age and menstruation state(P ＞0.05).The expression of ki-67 correlate with hormone receptor status and histology pathology classification.Conclusion Ki-67 cannot serve as an important index of evaluating prognosis of breast cancer and to guide clinical treatment. Key words: Breast neoplasms;  Ki-67 antigen;  Immunohistochemistry