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2009•Strait Pharmaceutical JournalRequires access

Simultaneous determination of aspirin and salicylic acid in chewing aspirin tablets by HPLC

Wan Ji

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Abstract

OBJECTIVE An HPLC method for the simultaneous determination of aspirin and salicylic acid in chewing aspirin tablets was established.METHODS Diamonsil C18 column was used with methyl alcohol-acetic acid-water(45∶1∶54)as mobile phase.The flow rate was 1.0mL·min-1 and detecting wavelength was 275nm.RESULTS The linear range of aspirin was 0.54～10.85μg(r=0.9999)and average recovery was 100.9%,RSD=0.36%(n=5);The linear range of salicylic acid was 2.65～31.77μg·mL-1(r=1.0000) and average recovery was 102.3%,RSD=2.0%(n=5).CONCLUSION The method was simple,fast and accurate.

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OBJECTIVE An HPLC method for the simultaneous determination of aspirin and salicylic acid in chewing aspirin tablets was established.METHODS Diamonsil C18 column was used with methyl alcohol-acetic acid-water(45∶1∶54)as mobile phase.The flow rate was 1.0mL·min-1 and detecting wavelength was 275nm.RESULTS The linear range of aspirin was 0.54～10.85μg(r=0.9999)and average recovery was 100.9%,RSD=0.36%(n=5);The linear range of salicylic acid was 2.65～31.77μg·mL-1(r=1.0000) and average recovery was 102.3%,RSD=2.0%(n=5).CONCLUSION The method was simple,fast and accurate.

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Available abstract

OBJECTIVE An HPLC method for the simultaneous determination of aspirin and salicylic acid in chewing aspirin tablets was established.METHODS Diamonsil C18 column was used with methyl alcohol-acetic acid-water(45∶1∶54)as mobile phase.The flow rate was 1.0mL·min-1 and detecting wavelength was 275nm.RESULTS The linear range of aspirin was 0.54～10.85μg(r=0.9999)and average recovery was 100.9%,RSD=0.36%(n=5);The linear range of salicylic acid was 2.65～31.77μg·mL-1(r=1.0000) and average recovery was 102.3%,RSD=2.0%(n=5).CONCLUSION The method was simple,fast and accurate.

Key concepts: Salicylic acid, Aspirin, Chromatography, Chemistry, High-performance liquid chromatography, Acetic acid, Linear range, Linear relationship

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