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2002•Chinese Journal of ChromatographyRequires access

Determination of Aspirin and Free Salicylic Acid in Lysinipirine Injection by High Performance Liquid Chromatography

Zhao Yuan

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Abstract

The contents of aspirin and free salicylic acid in lysinipirine injection were determined by high performance liquid chromatography (HPLC). A Hypersil BDS C 18 column was used with the mobile phase of methanol water acetic acid (35∶65∶3, volume ratio) and the detection wavelength of 280 nm The average recoveries of aspirin and salicylic acid added were 99 27%(RSD=0 8%) and 99 61%(RSD=1 3%), respectively The calibration curves had good linearity in the range of 0 028 g/L-0 141 mg/L and 0 77 mg/L-3 85 mg/L, and the correlation coefficients were 0 999?9 and 0 999?8 for aspirin and salicylic acid respectively.

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What this paper is about

The contents of aspirin and free salicylic acid in lysinipirine injection were determined by high performance liquid chromatography (HPLC). A Hypersil BDS C 18 column was used with the mobile phase of methanol water acetic acid (35∶65∶3, volume ratio) and the detection wavelength of 280 nm The average recoveries of aspirin and salicylic acid added were 99 27%(RSD=0 8%) and 99 61%(RSD=1 3%), respectively The calibration curves had good linearity in the range of 0 028 g/L-0 141 mg/L and 0 77 mg/L-3 85 mg/L, and the correlation coefficients were 0 999?9 and 0 999?8 for aspirin and salicylic acid respectively.

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Available abstract

The contents of aspirin and free salicylic acid in lysinipirine injection were determined by high performance liquid chromatography (HPLC). A Hypersil BDS C 18 column was used with the mobile phase of methanol water acetic acid (35∶65∶3, volume ratio) and the detection wavelength of 280 nm The average recoveries of aspirin and salicylic acid added were 99 27%(RSD=0 8%) and 99 61%(RSD=1 3%), respectively The calibration curves had good linearity in the range of 0 028 g/L-0 141 mg/L and 0 77 mg/L-3 85 mg/L, and the correlation coefficients were 0 999?9 and 0 999?8 for aspirin and salicylic acid respectively.

Key concepts: Salicylic acid, Chemistry, Chromatography, Aspirin, High-performance liquid chromatography, Acetic acid, Calibration curve, Methanol

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Determination of Aspirin and Free Salicylic Acid in Lysinipirine Injection by High Performance Liquid Chromatography — Research Paper | ScholarLens