2003•PubMedRequires access

Determination of free salicylic acid in chewing aspirin tablets by HPLC.

Jun Tian, Xin-shan Chen, Wang Rui-dong

Abstract

OBJECTIVE: To establish a HPLC method for determining the content of free salicylic acid in chewing aspirin tablets. METHOD: The determination was conducted on a HPLC column (C(18), 150 mm x 4.6 mm x 5 microm) with methanol-water-glacial acetic acid (8.0 5.5 1.0) as the mobile phase and the detection wavelength of 302 nm. RESULTS: The calibration curve was linear within the concentration range of 2.65 to 31.77 microg/ml (r=0.999 97) of salicylic acid. The average recovery rate was 100.21% with relative standard deviation of 0.53% (n=6). CONCLUSION: HPLC is quick and accurate of determining the content of free salicylic acid for chewing aspirin tablets.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Salicylic acid, High-performance liquid chromatography, Chromatography, Aspirin, Calibration curve, Acetic acid, Chemistry, Methanol