Preparation and Quality Control of Compound Ornidazole Effervescent Suppository

Objective To prepare the compound ornidazole effervescent suppository and establish a method for its quality control.Methods Ornidazole was compatible with miconazole nitrate to form the effervescent suppository,the content of which were determined with high performance liquid chromatography(HPLC),the stability was tested.Results The preparation was stable.The method for content determination was accurate with a good linear range at the concentration of 40~200 μg·mL-1 for both ornidazole and miconazole nitrate.Their average recovery was 100.09%(RSD=0.15%),100.02%(RSD=0.35%),respectively.Conclusion The prescription and preparation technology of compound ornidazole effervescent suppository is rational and the quality shows stable and controllable.