Manufacture and Quality Control of the Vaginal Suppository of the Compound Gatifloxacin

Objective To prepare the vaginal suppository consisting of gatifloxcacin and ornidazole and to establish quality control.Methods Production was finished with the melting by principal excipient of S-40.The contents of the gatifloxcacin and ornidazole in suppository were deterrmined by dual wavelength UV spectrophotometry.Results The average recovery of gatifloxcacin and ornidazole was 99.36%(RSD=1.37%) versus 101.05%(RSD=0.86%),the suppository had good stability and no stimulation.Conclusion The preparation is simple and feasible,the method of assay is accurate.The vaginal suppository warrants for the hospital pharmacy compounding.