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Determination of astragaloside in Yiqibuxue Granules and Radix Astragali by HPLC-ELSD

Yan Guang-jun

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Abstract

OBJECTIVE An HPLC-ELSD method for determination of astragaloside in Yiqibuxue Granules and Radix Astragali was established.METHODS The chromatographic system consisted of Hypersil C18(4.6×250mm,5μm) and mobile phase of methanol-water(75∶25).The flow rate was 1mL·min-1,column temperature was 40℃.RESULTS The linear range was 0.74~5.55μg.The average recovery was 98.37%,RSD was 1.58%(n=6).CONCLUSION The method was simple,rapid and reproducible,and can be used for quality control of Yiqibuxue Granules.

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OBJECTIVE An HPLC-ELSD method for determination of astragaloside in Yiqibuxue Granules and Radix Astragali was established.METHODS The chromatographic system consisted of Hypersil C18(4.6×250mm,5μm) and mobile phase of methanol-water(75∶25).The flow rate was 1mL·min-1,column temperature was 40℃.RESULTS The linear range was 0.74~5.55μg.The average recovery was 98.37%,RSD was 1.58%(n=6).CONCLUSION The method was simple,rapid and reproducible,and can be used for quality control of Yiqibuxue Granules.

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Available abstract

OBJECTIVE An HPLC-ELSD method for determination of astragaloside in Yiqibuxue Granules and Radix Astragali was established.METHODS The chromatographic system consisted of Hypersil C18(4.6×250mm,5μm) and mobile phase of methanol-water(75∶25).The flow rate was 1mL·min-1,column temperature was 40℃.RESULTS The linear range was 0.74~5.55μg.The average recovery was 98.37%,RSD was 1.58%(n=6).CONCLUSION The method was simple,rapid and reproducible,and can be used for quality control of Yiqibuxue Granules.

Key concepts: Astragaloside, Radix (gastropod), Chromatography, Chromatography detector, High-performance liquid chromatography, Chemistry, Linear range, Detection limit

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