Analgesic effect of parecoxib sodium and oxycodone for postoperative pain after total knee arthroplasty

Objective To investigate the analgesic effect of parecoxib sodium and oxycodone for postoperative pain after total knee arthroplasty. Methods Sixty patients undergoing elective TKA were randomly divided into 2 groups( n =30 each) : parecoxib group( group A),parecoxib and oxycodone group( group B). All the patients were received parecoxib sodium for analgesia at the first 24h after surgery. From then on,if the visual analogue score( VAS) 5 the supplements( parecoxib sodium,oxycodone) would be infused in turn till the patient felt comfortable or the analgesic effect reached the clinical maximum. The VAS and Ramsay sedation score( RSS) were recorded at 24,32, 40,48,and 72 hours after surgery. Adverse effects related to analgesia and the maximum tolerable degree of passive exercise were investigated and compared between the two groups. Results Compared with group A,the resting and exercising VAS was decreased in group B at 24,32,40,48,and 72 hours after surgery,while the sedation score increased( P 0. 05). And the maximum tolerable degree of passive exercise was higher in group B at the 48 and 72 hours after surgery( P 0. 05). No serious adverse effects occurred between the two groups. Conclusions Intravenous injection of parecoxib sodium combined with oral oxycodone is consistent trend of multimodal analgesia. It can realize the basic goal of postoperative analgesia in patients undergoing total knee arthroplasty.