Application of parecoxib for postoperative analgesia in arthroscopic surgery of the knee

Objective:To investigate effectiveness of parecoxib sodium for postoperative analgesia in arthroscopic surgery of the knee.Methods:In 60 patients(ASA I or II,aged 18~50 yr,scheduled for elective arthroscopic surgery of the knee) were randomly divided into three groups(n=20 for each group).Patients were intravenously injected with parecoxib sodium 40 mg before or at the end of surgery,or with equivalence saline(control).The intensity of pain was evaluated using VAS score(0~10,0=no pain,10=worst pain) at 2,6,12,24 h after operation.The adverse effects,the needs of postoperative analgesic drugs and the patients' global evaluation of the postoperative analgesia were recorded and compared 24 h after the operation.Results:As compared with control,parecoxib administered both before and after surgery significantly reduced the needs of postoperative analgesic drugs at 24 h,the VAS scores after operation,and the adverse effects(P0.05).Meanwhile,the patients in both parecoxib groups were more satisfied for the postoperative analgesia than those in control group(P0.05).The VAS scores at 6,12 h after operation were significantly less when parecoxib was injected at the end of surgery.Conclusion:Intravenous parecoxib sodium(40 mg) has a potent analgesic effect,reduces the percentage of adverse effects,and improves postoperative analgesic effect.Pre-operative application of parecoxib may be more effective.