Preparation of Qufeng Zhibi Gel and its Skin Penetration Properties in Vitro

Objective To prepare Qufeng Zhibi gel and study its skin penetration in vitro.Methods Qufeng Zhibi gel was prepared with Carbomer 940,hydroxypropyl methylcellulose (HPMC)and polyvinylpyrrolidone (PVP) as base materia1s.Using improved Franz-type diffusion cell and isolated mice skin as transdermal barrier,the cumulative permeation quantity of sinomenine was determined by HPLC method.Results The penetration equation of sinomenine in Qufeng Zhibi gel was Q=57.226t-103.88 (r =0.9961).The cumulative permeation quantity of sinomenine in 20 h was 1012μg/cm-2.Conclusion The penetration of sinomenine from Qufeng Zhibi gel through the mice skin follows zero-order kinetics.