ScholarLens Back to search
2009•The Chinese Journal of Modern Applied PharmacyRequires access

Studies on Preparation and Transdermal Absorption through Rat Skin of Sinomenine Gel

Li Li

Open publisher page 0 citations

Abstract

OBJECTIVE To study the preparation of sinomenine gel and transdermal absorption of gel through rat skin.METHODS Cabapol was used as gel material to prepare sinomenine gel. The permeability of sinomenine through rat skin was evaluated by using the TK-12A type diffusion cells. RESULTS Cabapol showed it was a suitable material for gel preparation and had larger permeation flux, and the effect of 10% propanediol in absorption of sinomenine from cabapol gel through rat skin was not obvious. CONCLUSION Sonimenine-containing gel with cabapol is suitable for transdermal delivery of drug.

About this research paper

What this paper is about

OBJECTIVE To study the preparation of sinomenine gel and transdermal absorption of gel through rat skin.METHODS Cabapol was used as gel material to prepare sinomenine gel. The permeability of sinomenine through rat skin was evaluated by using the TK-12A type diffusion cells. RESULTS Cabapol showed it was a suitable material for gel preparation and had larger permeation flux, and the effect of 10% propanediol in absorption of sinomenine from cabapol gel through rat skin was not obvious. CONCLUSION Sonimenine-containing gel with cabapol is suitable for transdermal delivery of drug.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

OBJECTIVE To study the preparation of sinomenine gel and transdermal absorption of gel through rat skin.METHODS Cabapol was used as gel material to prepare sinomenine gel. The permeability of sinomenine through rat skin was evaluated by using the TK-12A type diffusion cells. RESULTS Cabapol showed it was a suitable material for gel preparation and had larger permeation flux, and the effect of 10% propanediol in absorption of sinomenine from cabapol gel through rat skin was not obvious. CONCLUSION Sonimenine-containing gel with cabapol is suitable for transdermal delivery of drug.

Key concepts: Sinomenine, Transdermal, Chromatography, Permeation, Chemistry, Absorption (acoustics), Materials science, Pharmacology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
Studies on Preparation and Transdermal Absorption through Rat Skin of Sinomenine Gel — Research Paper | ScholarLens