Clinical Analysis of TCM Differential Treatment on Severe Chronic Hepatitis B

Objective:To explore the survival rate and its therapeutic of the TCM differential treatment on severe chronic hepatitis B(CSHB)patients.Methods:According to requirements of the major science and technology projects of National 11th five-year plan-the TCM syndromes characteristics and combined therapy of traditional Chinese medicine and western medicine of severe chronic hepatitis B,we used forward-looking research methods.The patients that from May 2009-January 2010 in Hangzhou Sixth People's Hospital of CSHB in groups were observed,they were randomly divided into test group and control group,we gave control group based treatment and symptomatic treatment,the test group were given basic treatment,symptomatic treatment,TCM differential treatment and herbal enema.They were followed for 48 weeks,their survival time and biochemical indicators were monitored.At the end 53 patients of the test group and 50 patients of control group finished the research.Results:(1)There were significant difference in cumulative survival rate between the two groups,the difference was statistically significant(P0.05),the cumulative survival rate of test group was significantly higher than that of control group in each time.(2)The total bilirubin(TBil)and prothrombin time(PT)were at a high level in each group at the first week,the difference had no statistical meaning,but in the 4th and 8th week the TBil and PT were significantly different between the two groups.In the test group,the TBil and PT were significantly higher,the difference was statistical.12 weeks later,the TBil and PT in each group were at a low level,the difference was not statistically significant.The AFP levels were also observed,the test group was commonly higher than control group,but the difference was not statistical.Conclusion:Based on the basic treatment and symptomatic treatment,TCM differential treatment and herbal enema can significantly improve the survival rate,slow down the rate of progression of the disease,improve the prognosis,and lower patients total bilirubin as well as prothrombin time index.