Effects of the Different Laxatives in the Treatment of Senile Functional Constipation

Objective To investigate the clinical effects of different laxatives in the treatment of senile functional constipation.Methods A total of 197 patients with functional constipation admitted into our hospital between January 2007 and April 2013 underwent colonoscopy to exclude colon and rectal lesions.The subjects were divided into four groups according to their medication: group A with mosapride,group B with mosapride and lactulose,group C with fiberform and lactulose,and group D with mosapride,fiberform and lactulose.The course of treatment was 4 weeks.Information about defecation frequency,defecation time,feces features,abdominal distention,abdominal pain,and non-complete defecation after treatment was collected among the patients.The recurrence rates at four weeks and eight weeks after withdrawal were also recorded.Results The Ridit analysis showed that the treatment effects in group B,C,and D were better than that in group A(P = 0.035).The recurrence rates at 8 weeks after withdraw were lower in group B,C,and D than in group A(P 0.05).Conclusion Combination therapy is more effective and safer,and had lower recurrence rate than mono-therapy in treating senile functional constipation.