Observation of the curative effect of Edaravone on intracerebral hemorrhage

Objective To observe the curative effect of Edaravone on intracerebral hemorrhage(ICH).Methods 122 ICH patients were randomly divided into Edaravone group(61 cases) and routine group(61 cases).On the basis of routine therapy for the two groups,the Edaravone group received Edaravone 30 mg with normal saline 100 ml intravenous drip twice a day for 14 d.The levels of serum S-100β protein(S-100β),neuron-specific enolase(NSE) were detected before and 3 d,7 d and 14 d after treatment.The score of neurologic dysfunction(NDS) was evaluated before and 7 d,14 d,28 d after treatment.The volumes of hematoma and edema were measured by skull CT scan before and 7 d,21 d after treatment.The curative effect and Barthel index(BI) were evaluated at 28 d and 90 d after treatment.Results Compared with before treatment,the levels of serum S-100β and NSE,the NDSs,the volumes of hematoma and edema were obviously improved at each time point after treatment in the two groups(all P0.01),the more obvious in the Edaravone group(all P0.01).Total effective rate and obvious effective rate in the Edaravone group(86.89%,21.34%) were remarkable higher than those in the routine group(63.93%,9.84%)(all P0.01).Conclusions Edaravone has better short and long-term curative effects for ICH patients by decreasing neurocyte injury and promoting neurofunctional recovery.