2013•Jiepou kexue jinzhanRequires access
The effect of recombinant human erythropoietin on the expression of STAT5 in the acute spinal cord injury rat
Hongpeng Li
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Abstract
Objective To study the effect of recombinant human erythropoietin(rHuEPO) on the expression of signal transducer and activator of transcription 5(STAT5) in the acute spinal cord injury rat.Methods 72 healthy adult SD rats were chose and randomly divided into the sham group,the acute spinal cord injury group and the recombinant human erythropoietin group.The spinal cord injury was established by Nystrom' s way.The expression of STAT5 in T10 segment was detected by immunochemistry and Western blot methods.Results Plenty of the positive STAT5 product in T10 segment of the spinal cord was found in sham group,and the positive expression level of STAT5 decreased significantly in spinal cord injury group than in sham control,lowest at 3 days after the injury,abut increassed significantly in rHuEPO treated group than in the acute spinal cord injury group by immunochemistry and Western blot methods.Conclusion rHuEPO can upregulate the expression of STAT5 in acute spinal cord injury rats.