2007•Hebei Journal of Traditional Chinese MedicineRequires access
Effect of Duhuojisheng decoction on IL-1 and TNF from synovial fluid in rabbit with osteoarthritis
Wang Xiangli
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Abstract
Objective To observe the effect of Duhuojisheng decoction on the expression of IL-1 and TNF from synovial fluid in rabbit with osteoarthritis. Methods 24 rabbits were randomly divided into control and treatment groups. There were 12 rabbits (24 articular genus) in every group. Osteoarthritis model was established by injection of caroid in articular genu intracavitary. Rabbits with osteoarthritis were interfered by Duhuojisheng decoction. The expression of IL-1 and TNF from synovial fluid in rabbit with osteoarthritis were measured by double antibody sandwich ELISA 1, 3, 5 weeks after treatment. Results There were expression of IL-1 and TNF from synovial fluid a week after treatment. Following weeks expression of IL-1 and TNF raised in control group. In 3 weeks peak appeared. Expression of IL-1 and TNF raised in treatment group decreased compared with those in control group (P0.01, P0.05). Conclusion Duhuojisheng decoction can depress the expression of IL-1 and TNF in osteoarthritis.