The Effect of Miao Medicine Jinwujiangu Decoction on Serum IL-1,IL-1β and TNF-α of Model Rats with Collagen Induced Arthritis

Objective: To investigate the effect of the Miao medicine Jinwujiangu Decoction on the serum TNF- α,IL- 1,and IL-1βof model rats with collagen induced arthritis( CIA). Methods: 60 Wistar rats were randomly divided into six groups,with 10 rats in each. Except the blank control group,collagen-induced arthritis( CIA) models were established in other groups. From the eighth day,model control group were given Jinwujiangu decoction of high,middle and low doses and treatment group and respectively,while blank group and control group were given equal of amount group expression of the serum TNF- α,IL- 1,IL- 1β was detected by ELISA. Results: The expression of serum inflammatory factors( TNF- α、IL- 1、IL- 1β) of CIA rats have different degrees of improvements in different doses Jinwujiangu Decoction treatment groups and tripterygium wilfordii glycosides group,compared to model group,have significant difference( P 0. 01). Conclusion: The Jinwu jiangu decoction can significantly decrease expression of serum inflammatory factors TNF- α、IL- 1、IL- 1βa in CIA rats.