Establishment of mice alcoholic fatty liver model

Objective To establish an animal model of alcoholic fatty liver.Methods Mice were exposed to absolute alcohol continuously for up to 15 days via an intragastric feeding.The pathologic and bichemistry alteration of the liver and the changes of serum lipid were observed.Results The weight of model group was higher than those of normal group.Wide hepatic steatosis was induced in model group.Serum triglyceride(TG),alanine aminotransferase(ALT)and total cholesterol(CHOL) of the model group were higher than those of normal group(P0.01).Liver triglyceride(TG),alanine aminotransferase(ALT) and total bilirubin(TBIL) of the model group were higher than those of the normal group(P0.01).For liver CHOL,male mice between model and normal group,was difference,but femal mice was same.Conclusion AFL model of mice established by feeding the absolute alcohol is similar to the episode of the human AFL.