The significance of detecting high-risk human papillomavirus for evaluating the prognosis of cervical intraepithelial neoplasia after loop electrosurgical excisional procedure

Objective To explore the significance of detecting high-risk human papillomavirus(HPV) for evaluating the prognosis of cervical intraepithelial neoplasia(CIN) after loop electrosurgical excisional procedure(LEEP).Methods LEEP was performed on 560 women with CIN confirmed by cervical biopsy.Loading dose of HPV before and after LEEP was detected.All the patients were followed 1 year.The persistence or recurrence of the lesions was reviewed.Results Before LEEP,the rate of high-risk HPV infection was 32.63% in CIN Ⅰ patients,90.85% in Ⅱ,and 98.13% in Ⅲ and differed significantly between the CIN Ⅰ group(low-grade squamous intraeplthellal lesions) and the other two groups(high-grade squamous intraeplthellal lesions)(P 0.001).The rate of high-risk HPV infection elevated with aggravation of the cervical disease.6 months after LEEP,the infection rate was 2.54%,12.80%,and 25.23%,respectively.And it was 0.88%,9.15%,and 22.43% 1 year later.The infection rate declined significantly in all the three groups after LEEP(P 0.001).The persistence rate of the lesions was 1.69%,6.71%,and 12.15%,and the recurrence rate was 0%,7.32%,and 10.28% in the three groups,respectively.A significant difference was observed between CIN I group and the other two groups(P 0.001).Persistent HPV infection suggested persistence or recurrence of the disease.Conclusions Loop electrosurgical excisional procedure can significantly decrease the rate of high-risk HPV infection rate and is an effective method for CIN.High-risk HPV detection after LEEP is an available approach for evaluating prognosis.