Research Progress in Separation and Purification of Total Flavonoids of Seabuckthorn Leaves Extract

The separation and purification of total flavonoids from Hippophae rhamnoides leaves were reviewed by referring to relevant literature at domestic. The results showed that there are the total flavonoids,separation and purification method with X-5 macroporous adsorption resin purification method,amino resin adsorption purification method,FL-1 multifunctional adsorption resin purification method,silica gel,silica gel G purification,separation and purification method of Wakogel40C18 and silica gel column chromatography purification method. Although there are many separation and purification methods,with the increasing of the requirements for the effective part in new drug research and development,the methods for separating and purifying total flavonoids of seabuckthom leaves should be further optimized.