The expressions and significances of uPAR and PTEN in hepatocellular carcinoma

Objective:To study the expressions of uPAR and PTEN in hepatocellular carcinoma(HCC)and to evaluate their clinical significance to pathological features of HCC.Methods:Expression of uPAR and PTEN in 46 specimens of HCC and surrounding nonmalingnant hepatic tissues were detected with SP method of immunohistochemical technique to analyze its relationship with clinicopathological characteristics and invasion of HCC.Results:The positive expression intensity of PTEN in HCC was remarkably weaker than that in surrounding nonmalingnant hepatic tissues(P0.05),while the expression intensity of uPAR was stronger in HCC than that in surrounding nonmalingnant hepatic tissues(P0.05).Moreover,there was a negative correlation between the expression of PTEN and that of uPAR(P0.05,r =-0.44).The positive expression rate of uPAR and PTEN in HCC were related to tumor Edmondson grade and the invasion severity(P0.05).The expression of PTEN in HCC was also related to portal emblous and TNM tumor stage(P0.05),while not to age,sex,hepatocirrhosis,pathology type of HCC,AFP,HbsAg and diameter of the tumor(P0.05).Conclusions:The abnormal expression of uPAR and PTEN in HCC may play some roles in the origin and development of HCC,and can reflect the differentiation and invasive potential of HCC tissues.