Expression of PTEN,p73 in Hepatocellular Carcinoma and Its Clinical Significance

[Purpose]To investigate the expression of PTEN,p73 in hepatocellular carcinoma(HCC) and to investigate its correlation in the progression of HCC. [Methods] The expression of PTEN,p73 proteins in HCC tissue and the adjacent noncancerous tissue in 53 cases with HCC was determined by Elivision immunohistochemistry . [Results] The positive expression of PTEN in HCC tissue (56.6%) was lower than that in adjacent noncancerous tissue(96.2%) in 53 cases(χ2=20.94,P0.01). The positive expression of p73 in HCC tissue (54.7%) was higher than that in adjacent noncarcerous tissue(5.7%)(χ2=26.33,P0.01). The expression of PTEN proteins was significantly related with invasion and histological differentiation of HCC (P0.01); but not related with size of tumor,TNM stage and hepatic cirrhosis(P0.05). The expression of p73 protein was related with invasion of HCC (P0.05); but not related with size of tumor, histological differentiation , TNM stage and hepatic cirrhosis of HCC (P0.05).No correlation was observed between PTEN and p73 expression. [Conclusion] It suggests that PTEN,p73 may play an important role in progression of HCC. Combined examination of PTEN and p73 might make a referenced value for evaluating prognosis of HCC.