Distribution and drug resistance of pathogens causing lower respiratory tract infections in children

OBJECTIVE To investigate the major pathogens isolated from children with lower respiratory tract infections and their drug resistance to commonly used antibiotics so as to provide basis for clinical reasonable use of antibiotics.METHODS Sputum samples obtained from 3335 children patients were cultured.MicroScan WalkAway 40 was used to assess the bacteria and test the drug sensitivity.The data were analyzed with software WHONET 5.4.RESULTS Totally 1659 isolates were detected in totally 3335 sputum specimens,including 1423 strains of gram-negative bacilli(85.8%),218 strains of gram-positive cocci(13.1%),and 18 strains of fungi(1.1%),with the isolation rate of 49.7%.Klebsiella pneumoniae and Escherichia coli were the main gram-negative strains in which the detection rates of extended-spectrum β-lactamases(ESBLs) were 31.1% and 43.0%,respectively,the resistance rate of these isolates to imipenem was low;S.aureus was the main gram-positive cooci and most susceptible to vancomycin and linezolid.CONCLUSION The gram-negative bacteria are the main pathogens and different bacterial species varied significantly in the antibiotics resistance.The clinic should strengthen the detection of the pathogens and select antibiotics on the basis of drug susceptibility testing so as to improve the therapeutic effect and delay the bacterial resistance.