Valsartan and alprostad il in treatment of 120 cases of early diabetic nephropathy

Objective To study the clinical effect of valsartan and alprostadil in treatment of early diabetic nephropa thy.Methods The 120 cases of early diabetic nephropathy were selected for the study,all patients were randomly divided into observation group and control group;observation group were treated with valsartan lowering proteinuria and control group were treated with plus alprostadil improve microcirculation on basis of the observation group.Two groups were treated for two weeks,the effect was compared.Results The symptom score and urinary albumin excretion rate was significantly lower than the control group after two weeks,observation group was 42 cases of effective,34 cases of ineffective,total effective rate was 82.50%,control group was 38 cases of effective,61 cases ineffective,the total effective rate was 71.67%;observation group was significantly better than the control group,the difference was significant(P 0.05).Conclusion Valsartan alprostadil treatment of early diabetic nephropathy can significantly reduce proteinuria,and improve diabetic nephropathy hypercoagulable state,help to improve the glomerular filtration rate,delaying renal failure.