Comparison of the Effect of Paclitaxel and 5-Fluorouracil Combined with Cisplatin in the Treatment of Liver and Lung Metastasis Tumors from Advanced Nasoplaryngeal Carcinoma

Objective To explore the effect and toxic side-effect of paclitaxel plus cisplatin(TP regiment) and 5-Fluororacil plus cisplatin combination chemotherape in the treatment of liver and lung metastasis tumors from advanced nasoplaryngeal cancer. Methods 56 patients who received 211 course treatment with TP(30 cases) or DF(26 cases) regiment were retrospectively analyzed and compared the toxic side-effect. The patients were divided two groups. The first group with 30 patients was treated with TP regiment. The second group with 26 patients was treated with DF regiment. Each treatment cycle was three weeks. Each patient received no less than 2 courses of treatment. It was anlayzed the effective median survival time and the proportion of main side-effect which was determined by the leucocyte quantity, platelet quantity, nausea, vomiting, diarrhoea, mucositis and alopecia. Results It shows the effective rate of TP regiment was 73.33%, which was apparently higher than 46.15%(P0.05) in DF regiment group. The median survival time was 11.8 and 9.8 months in TP and DF regiment group, respectively. But the difference was not significant when analyzed by logrank study (P0.05). The main toxic side-effects were alopecia (100%), leucocyte reduction (83.33%) and platelet reduction (50%) in TP regiment group. The obvious side-effects in DF regiment were nausea and vomiting (76.92%), diarrhea (73.07%) and mucositis (46.15%). Conclusion The treatment effect and median survival in TP regiment group were apparently higher than those in DF regiment group. The toxic side-effects were tolerable and mild.