Comparison of TP and NP Regimen in Patients with Advanced Non-small Cell Lung Cancer

Objective To comparison the efficacy and toxicity of TP and NP chemotherapeutic regimens for patients with advanced non-small cell lung cancer(NSCLC).Methods Ninety-seven patients confirmed as Stage IV NSCLC with histology or cytology were randomly divided into two groups: 49 patients received paclitaxel-cisplatin(TP regimen) and 48 patients received navelbine-cisplatin(NP regimen).Paclitaxel 135 mg/m2 by infusion on day 1 and cisplatin 40 mg/m2 by infusion on day 2～4 in TP.Navelbine(NVB) 25 mg/m2 by infusion on day 1,8 in NP,and cisplatin was same to TP.The treatment was repeated every 4 week.Results The objective response rate was 57.14% in TP regimen,the Median survival time was 9 months.The objective response rate was 60.42% in NP regimen,the Median survival time was 10 months.There was no significant difference between the two regimens.The major side effects were leukopenia,alopecia and nausea/vomiting in the two groups.The was no significant different in leukopenia and alopecia between TP regimen and NP regimen(87.76% vs 93.75%,P0.05,85.71% vs 79.17%,P0.05, respectively).The incidences of nausea/vomiting and pain of joint and muscle occurred more frequently in TP group than those in NP group.Conclusions Both TP and NP regimens have similar good effect for advanced non-small cell lung cancer.Side effects were well tolerated.