Retrospective Analysis on the Relationship Between the Increase of Serum Uric Acid and Pregnancy

Objective To discuss the relationship between gestation and the level of blood uric acid.Method From January to December 2007,1980 pregnant women were divided into 4 groups,60 cases with the increase of serum uric acid(group A),77 cases with pre-eclampsia(group B),88 cases with gestational diabetes mellitus(group C),and other 1920 cases with normal serum uric acid(group D).At the same time,200 pregnant women without any abnormal who were selected randomly from group D were taken as control group(n=200).The clinical data of all those patients were statistically analyzed.Informed consent was obtained from all participates.Results The increase possibility of urine protein of group A was higher than that of control group,especially the abnormal increase of urine protein(proteinuria≥0.3 mg/dL),there had statistical significance between two groups(χ2=0.66,P0.05).The mild increase possibility of urine protein of group A was similar to group B,but abnormal increase possibility of group B(proteinuria≥0.3 mg/dL) was significant higher than that of group A(χ2=38.68,P0.01).There had no significant differences of mild or severe increase possibility of urine protein between group A and C(χ2=0.08,P0.05;χ2=0.17,P0.05).The prevalence of pre-eclampsia and gestational diabetes mellitus in group A was higher than that of group D(χ2=12.28,P0.01;χ2=18.90,P0.01).Conclusion The increase of serum uric acid appears to be useful in forecasting the dysfunction of kidney in pregnancy,but it can not be one of sensitive indexes to examine pre-eclampsia.The increase of level of serum uric acid may raise prevalence of pre-eclampsia and gestational diabetes mellitus during pregnancy.