The study of different doses lovastatin in patients of acute coronary syndrome in early stage

Objective To investigate the safety and efficacy of two different doses lovastatin in patients of acute coronary syndrome(ACS) in early stage. Methods 153 consecutive patients with ACS were divided into two groups randomly;group 1(n=77) was given 40mg/d lovastatin at night,group(2=76) was given 10mg/d lovastatin. The efficacy of lovastatin therapy,drug adverse reaction were recorded in 6 month follow up.Results Compared with those before treatment, the total plasma cholesterol,triglyceride,low density lipoprotein, aplipoprotein B,heightening high desisity lipoprotein and apolipoprotein A decreased significantly at 6 week and 6 month after treatment in both groups(P0.05).There was significant difference in the two groups after treatment(P0.05).According to China Heart Association Suggestion:Abnormal of blood-lipid in prevention and treatment, Group 1 was better than group 2 in reaching to target blood-lipid goal level on total cholesterol and lower density lipoprotein(P0.05).There were significantly different in fibrinogen, C-creatin protein and plasma D-dimer in the two groups after 6 weeks treatment(P0.01).The drug adverse reaction was mild and similar in two groups. Conclusions The use of 40mg/d lovastatin seems safety and efficacy in heightening target blood-lipid goal rate,inhibiting inflammation factor.The early use of lovastatin 40mg/d will be good in safety, efficacy and tolerance.