Efficacy and Safety of Different Doses of Rosuvastatin Calcium in treating Elderly Coronary Heart Disease Patients with Hyperlipidemia

Objective To explore the efficacy and safety of different doses of rosuvastatin calcium in treating elderly coronary heart disease patients with hyperlipidemia. Methods Ninety elder coronary heart disease patients with hyperlipidemia were randomly divided into groups A,B and C according to the random number table,with 30 cases in each group. The patients in three groups were all given conventional treatment for coronary heart disease. In addition,the patients in group A were given rosuvastatin calcium 5 mg orally,the patients in group B were given rosuvastatin calcium10 mg orally,and the patients in group C were given rosuvastatin calcium 20 mg orally. All the patients were taken the medicine once a day after dinner. After 4 months of treatment,the blood lipid levels,cholesterol compliance rates and adverse events of three groups were compared. Results The levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol of three groups decreased significantly in contrast with those of pre-treatment,while the level of high-density lipoprotein cholesterol increased significantly in contrast with that of pre-treatment( all P 0. 05). After the treatment,the levels of total cholesterol,triglycerides,low-density lipoprotein cholesterol of group C were significantly lower than those of group A and group B,while the level of high-density lipoprotein cholesterol were significantly higher than that of group A and group B( all P 0. 05). After the treatment,the compliance rates of cholesterol and low-density lipoprotein cholesterol of group C( 86. 67%,83. 33%) were significantly higher than those of group A( 56. 67%,73. 33%) and group B( 53. 33%,73. 33%)( P 0. 05). The incidences of adverse reactions of groups A,B and C were 6. 67%,6. 67% and 10. 00%,respectively. There were no serious adverse reactions. No significant difference was found in the incidence of adverse reactions among three groups( P 0. 05). Conclusion Large doses of rosuvastatin calcium can control blood lipid level more effectively in elderly coronary heart disease patients with high safety.