Efficacy of different dosage of Lovastatin in patients with coronary disease combined hyperlipidemia

Objective:To observe the efficacy of the different dosage of Lovastatin on blood lipid level and reactive protein in patients with coronary heart disease combined hyperlipidemia.Methods:120 patients with coronary disease combined hyperlipidemia were randomly divided into two groups,group A took Lovastatin 20 mg,group B took Lovastatin 40 mg.The patients' TC,LDL-C,TG,HDL-C,CRP and CK were detected after 4 weeks and 8 weeks.The efficacy and safety of different doses of Lovastatin were compared.Results:The levels of TC,TG,LDL-C and CRP were reduced significantly by Lovastatin in patients after 4 weeks(P0.01 or P0.05),group B was better than group A(P0.05).Conclusion:Large dosage of Lovastatin is better than routine dosage in the treatment of coronary heart disease combined hyperlipidemia and both methods have good safety.