Expression of estrogen receptor β1 in colorectal adenocarcinoma and its clinicopathological significance

Objective: To probe the expression of estrogen receptor β1(ERβ1) in colorectal adenocarcinoma and their clinical significance.Methods: Paraffin-embedded tissue of 91 cases of colorectal adenocarcinoma were collected and tissue microarray was prepared.Normal colorectal mucosa near to colorectal carcinoma was used as control.Expression of ERβ1 was detected by immunohistochemical staining and the clinicopathological significance was analyzed.Results: The expression rates of ERβ1 in colorectal adenocarcinoma and normal colorectal mucosa were 46.15%(42/91) and 62.64%(57/91)(P=0.018) respectively.ERβ1 expression in male patient(61.54%) was significantly higher than that in female(34.62%)(P=0.01),and there was no correlation between ERβ1 expression with patients’age,the depth of tumor invasion,clinical stages,histological grading,lymph node metastasis,and remission.The expression of ERβ1 in normal colorectal mucosa of male patients(74.35%) was higher than those of female(53.85%),(P=0.036).The expression of ERβ1,AR and PR was negative in all cases.Conclusion: ERβ1 is expressed in colorectal adenocarcinoma and normal mucosa.The loss of ERβ1 expression maybe involved in contribute to the development of colorectal adenocarcinoma.