Study on the reaction between serum sex hormones levels and essential hypertension

Objective: To investigate the possible relationship existing between serum sex hormones levels development of essential hypertension.Methods: Serum sex hormones(LH,FSH,E2,P,T) levels were determined with chemiluminescence immunoassay in 47 males and 45 post-menopausal women with essential hypertension as well as in 44 normotensive males and 40 normotenisive post-menopausal women serving as controls.Results: The serum E2,progesterone and testosterone levels in the hypertensive were significantly higher than those in the respective controls(P0.01),while serum LH and FSH levels were significantly lower with the exception of serum FSH in male hypertensive(vs controls,P0.05).Sex hormones levels were not much different among hypertensive of various stages(Ⅰ,Ⅱ,Ⅲ).The serum E2 levels in male hypertensive and progesterone levels in female hypertensive were not correlated with the respective FSH and LH levels.Conclusion: The authors suggest that the changes of serum sex hormones levels might be a risk factor rather than a consequence of the development of essential hypertension.