2002•Chinese journal of integrated traditional and Western medicineRequires access
Experimental Study of Effect of Concentrated Yigan Decoction and Qiangan Capsule on Hepatic Fibrosis in Rats
Feng Liyiug
Open publisher page 0 citations
Abstract
Objective: To study the therapeutic effects of Concentrated Yigan Decoction and Qianggan Capsule on hepatic fibrosis in rats as well as their relative mechanisms. Methods: Hepatic fibrosis in rats was induced by CCl4 and Concentrated Yigan Decoction or Qianggan Capsule was given after model establishment. The administration of the two formulas lasted for 10 weeks. Liver hydroxyproline (Hyp) and malondialdehyde (MDA) level were determined and histopathological changes were observed by optical microscopy. Results: In Concentrated Yigan Decoction and Qianggan Capsule therapeutic group, the contents of Hyp and MDA as well as degrees of hepatic fibrosis were markedly reduced repectively compared with those of model of natural recovering group. Conclusion: Concentrated Yigan Decoction and Qianggan Capsule both had remarkably therapeutic effects on hepatic fibrosis of rats. They could resolve the collagens accumulated in liver of rats and hepatic fibrosis could be reversible. Antiperoxidation of lipid might be related to the two formulas' therapeutic effects.