EXPRESSION AND SIGNIFICANCE OF CYCLIN D1, CYCLINE AND P27 IN GASTRIC CARCINOMAS

Objective To study the expression and its significance of cyclin D1,cyclin E and p27 protein in gastric carcinoma. Methods The expression of cyclin D1,cyclin E and p27 protein in 60 cases of gastric carcinoma were detected by immunostaining method. Results The positive rates of cyclin D1, cyclin E and p27 protein expression in gastric carcinoma were 41. 7% (25/60), 38. 3 % (23/60) and 36. 7 % (22/60), respectively. The expression of cyclin D1 was significantly correlated with Lauren type of tumor, the expression of cyclin E was significantly correlated with tumor differentiation, infiltration and stage, while the expression of P27 protein was significantly correlated with tumor infiltration,lymph nodes metastasis and stage. Further more, the expression of cyclin E was inversely correlated with the expression of p27. Conclusion Detection of cyclin D1,cyclin E and p27 expression in gastric carcinoma may be helpful in determining tumor progression.