2007•Shenyang Yaoke Daxue xuebaoRequires access
Preparation of sustained-release pellets of paracetamol
Zhao Peng
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Abstract
Objective To prepare paracetamol sustained-release pellets and investigate the drug release mechanism in vitro.Methods Extrusion-spheronisation method was used to prepare uncoated pellets.Eudragit NE30D dispersions were coated as a sustained-release layer in a fluid-bed equipment.The release mechanism of the drug from the pellets was studied.Results The main factors affecting the release rate were the type and the amount of the coating material applied.Release of the drug from pellets was in accordance with Higuchi equation.Conclusions The method and the formulation are proved to be successful in providing slow and steady release of paracetamol from sustained-release pellets.