Preparation and Release Behavior of Paracetamol Sustained-Selease Pellets

Objective In this paper we wanted to prepare paracetamol sustaied-release pellets and to study their release behavior.Methods Cenrifugal granulation method was used to prepare MCC pellets and paracetamol pellets respectively.On that basis Eudragit RS30D/RL30D as a coating material was adopted to coat the paracetamol pellets with a fluid bed spray processor.HPLC method was utilized to determine the release behavior of paracetamol sustained-release pellets.The coating prescription parameters were investigated and optimized with single factor experiments.Results The paracetamol sustained-release pellets coated with 10%coating material sustained released best,and the coating material consisted of Eudragit RS30D/RL30D(15:l,w/w),TEC(25%,w/w) and talc(40%,w/w).Conclusion These showed that paracetamol sustained-release pellets contained a characteristic of sustained-release and the established process and formula were simple and stable.