2000•Chinese Journal of PharmaceuticalsRequires access
Preparation of Paracetamol Sustained Release Pellets with Melt Method
Cui Tang
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Abstract
Paracetamol sustained release pellets were prepared using melt method.The orthogonal design table L4( 2 3) and multiple stepwise regression analyses were used to investigate factors influencing the process and formulation on drug release.By means of changing granulating times and the amounts of paraffin,glyceryl monostearate and pregelatinized starch,paracetamol sustained release pellets with the ideal release behavior in vitro were obtained.