Influence of valsartan on blood pressure and renal function in patients with essential hypertension complicated with diabetes

Objective To investigate the role of valsartan in the treatment of primary hypertension complicated with diabetes.Methods Forty patients with essential hypertension complicated with diabetes were randomly divided into treatment group(n=20) and control group(n=20).The treatment group was administered ramipril combined with valsartan while the control group only ramipril.Both groups were treated for 24 weeks.After treatment,the changes of the antihypertensive efficacy,24 h urinary protein,blood urea nitrogen(BUN),and serum creatinine(SCr) in both groups were observed.Results The overall antihypertensive efficacy rate(75.0%) was higher in the treatment group than that(70.0%)in the control group,but the difference was not statistically significant(P0.05).After treatment,24 h urinary protein level was significantly lower in both groups.But compared with the control group,the treatment group had more significant decrease.Conclusion The valsartan treatment for hypertension complicated with diabetes is safe and effective.It can better protect renal function.